Indicator or biomarker
Sweat secretory response
A measure of sweat gland secretion in response to stimulation
Hypotheses on this target 5
Telling states apart1
Direct measurement1
Indicator replacement
Telling states apart1
Mismatched measurements can create the apparent benefit of reducing sweat
Where this hypothesis actsSkin assessed with dry-air capsules versus minimally perturbing instruments under native microclimate conditions
What is proposedDistinguish native excess sweat secretion from measurement-induced apparent excess
With whatInstrument or assay
HowCompare capsule and native-microclimate assessments with co-registered measurements, calibrated humidity and airflow, and independent heat and water balances
Possible resultExpected disappearance of apparent excess secretion and cooling-preserving suppression benefits under native conditions
2026-09-21
Direct measurement1
Selecting skin samples by final stiffness may create a false link between past load and sweating
Where this hypothesis actsSweat glands after mechanical loading and an intervention that normalizes average skin stiffness
What is proposedAssess changes from baseline without selecting samples by final stiffness
With whatInstrument or assay
HowAnalyze all randomized samples with adjustment for baseline secretion and a prespecified equivalence margin; analyze selection by final stiffness separately
Possible resultPossible absence of a loading-history effect when all randomized samples are analyzed
2026-09-25