Live·Open questions in longevity research
All targets

Enzyme

Executioner caspases

Enzymes implicated in proteolytic cleavage of contractile-apparatus substrates

Hypotheses on this target 1

Executioner caspasesInhibition. Hypotheses on this target 0Activation. Hypotheses on this target 11Lower level. Hypotheses on this target 0Higher level. Hypotheses on this target 0Replacement. Hypotheses on this target 0Protection from degradation. Hypotheses on this target 0Cofactor removal. Hypotheses on this target 0Synthesis suppression. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Inhibition
  • Activation1
  • Lower level
  • Higher level
  • Replacement
  • Protection from degradation
  • Cofactor removal
  • Synthesis suppression
  • Function preservation

Activation1

  • Surviving skin fibroblasts must briefly dismantle their contractile machinery to stop pulling

    Where this hypothesis actsSurviving fibroblasts in aged skin after wound closure, under matrix tension

    What is proposedInduce a brief, nonlethal executioner-caspase pulse

    With whatNot stated in the record

    HowUse a calibrated caspase pulse with independently maintained survival; the pulse induction method is not stated in the record

    Possible resultPossible contractile-apparatus disassembly and force termination while fibroblasts survive and recover mobility

    2026-09-21