Signalling pathway
Excitation–secretion coupling
The coordination of cellular excitation with secretion within the same cell
Hypotheses on this target 1
Inhibition
Activation
Desensitisation
Function preservation1
Feedback restoration
Rhythm restoration
Function preservation1
Mechanical history may uncouple calcium entry from chloride flow within sweat-gland cells
Where this hypothesis actsSweat gland secretory cells with persistent functional defects after mechanical loading
What is proposedRestore calcium entry and calcium-dependent chloride conductance in the same cells
With whatNot stated in the record
HowCorrect both functions in the same cells, initially in a mosaic organotypic gland model, with mechanical load and duct patency matched
Possible resultExpected stronger recovery of primary sweat secretion and stabilization of the sweat component of SPV_8
2026-09-25