Live·Open questions in longevity research
All targets

Receptor or channel

IL-11 receptor alpha

The IL-11 receptor alpha component, denoted IL11RA

Hypotheses on this target 1

IL-11 receptor alphaLower level. Hypotheses on this target 11Higher level. Hypotheses on this target 0Blockade. Hypotheses on this target 0Agonism. Hypotheses on this target 0Desensitisation. Hypotheses on this target 0Function restoration. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Lower level1
  • Higher level
  • Blockade
  • Agonism
  • Desensitisation
  • Function restoration
  • Function preservation

Lower level1

  • Blocking interleukin-11 may shift genome repair toward error-prone end joining

    Where this hypothesis actsProspectively specified cycling epithelial progenitors from aging humans with an endogenous IL-11 response

    What is proposedDisable IL-11 receptor alpha to independently test the effects of IL-11 pathway blockade

    With whatControlled genetic model

    HowInducible IL11RA loss in randomized donor-paired comparisons, with separately validated receptor re-expression for rescue

    Possible resultPossible excess structural repair errors for comparable initial lesions, reversed by validated rescue

    2026-10-10