Mechanics and load
Transepithelial water transport
Movement of water across an epithelial layer
Hypotheses on this target 2
Inhibition1
Activation1
Function preservation
Remodelling
Load normalisation
Direct measurement
Inhibition1
Altered aquaporin placement may reduce sweat output by letting water return through duct walls
Where this hypothesis actsSweat gland ducts after repeated recovery cycles, with persistent changes in aquaporin membrane distribution
What is proposedReduce excessive water transport back across the duct wall into surrounding tissue
With whatPhysical or surgical intervention
HowLower the osmotic gradient across isolated, intact ducts during microperfusion while keeping secretory stimulation unchanged
Possible resultPossible restoration of fluid output and stabilization of the sweat component of SPV_8
2026-09-25
Activation1
Delayed gut delivery of rehydration fluid leaves the kidneys and brain undersupplied
Where this hypothesis actsDuring oral rehydration after heat exposure, when luminal fluid retention coexists with arterial underfilling
What is proposedIncrease actual systemic water delivery during rehydration
With whatChange of environment or regimen
HowStage oral rehydration to improve systemic water appearance; test causality by bypassing gastrointestinal delivery in a controlled translational preparation
Possible resultPossible recovery of renal filtration and cerebral perfusion as systemic water delivery improves
2026-09-18