Antibody
Tissue-binding antibodies
Antibodies that bind antigens in tissue
Hypotheses on this target 1
Lower level
Protection from degradation
Synthesis suppression
Neutralisation
Accelerated excretion1
Accelerated excretion1
Healing antibodies may trigger systemic inflammation through circulating immune complexes
Where this hypothesis actsSkin explants sharing circulating medium with autologous immune cells and active complement
What is proposedSelectively deplete tissue-binding antibodies to test their role in systemic inflammation
With whatRemoval from a body fluid
HowSelectively remove the antibodies, then add back purified original antibodies; compare with fragments lacking the Fc region
Possible resultPossible reduction in distant inflammatory activation, accompanied by slower local repair
2026-09-25