Rhythm or programme
ER-selective autophagy
The selective removal of endoplasmic reticulum through autophagy
Hypotheses on this target 1
Inhibition1
Activation
Function preservation
Feedback restoration
Rhythm restoration
Direct measurement
Inhibition1
Old plasma cells can survive a loss of antibody protection and later restore it
Where this hypothesis actsEstablished plasma cells in aged bone marrow during and after incoming vaccine-induced plasmablast waves
What is proposedTransiently reduce excessive ER-selective autophagy in established plasma cells
With whatNot stated in the record
HowResident-restricted manipulation of ER turnover with target-engagement validation; avoid global autophagy inhibition, which can kill plasma cells
Possible resultPossible recovery of antibody secretion and protective activity from the same surviving plasma cells
2026-09-21