Signalling pathway
Sensory afferent activity
Nerve signals carrying sensory input from peripheral tissues into central sensory circuits
Hypotheses on this target 7
Inhibition3
Activation
Desensitisation
Function preservation1
Feedback restoration1
Rhythm restoration
Inhibition3
The strongest skin nerve signal may sustain a body-wide response through competitive inhibition
Where this hypothesis actsRegenerating skin sites with persistent peripheral sensitization
What is proposedSelectively and reversibly suppress sensory input from individual sites
With whatSmall molecule
HowSelective reversible suppression of individual afferent inputs in an innervated experimental model; regional anesthesia in humans with control for direct inflammatory effects
Possible resultExpected reduction of the autonomic response to the next strongest input, with decay after all inputs are silenced
2026-09-25
Regrowing skin nerves can erase protective signals when opposing impulses collide
Where this hypothesis actsRegenerating sensory terminals with spontaneous antidromic impulses and inflammatory sensitization
What is proposedSelectively suppress antidromic impulse traffic
With whatNot stated in the record
HowReversible direction-selective suppression of antidromic traffic while retaining stimulus-evoked orthodromic transmission
Possible resultPossible restoration of protective signal transmission despite unchanged fiber density and inflammatory mediators
2026-09-21
Better oxygen delivery to restored muscle triggers signals that harm brain and lung circulation
Where this hypothesis actsRestored muscle in an aged host, where increased graft oxygenation abnormally increases sympathetic output
What is proposedInterrupt abnormal sensory input from the muscle graft
With whatNot stated in the record
HowReversible graft-afferent interruption using sensory blockade
Possible resultPossible protection against cerebral underperfusion and pulmonary congestion, with stabilization of SPV_6
2026-09-20
Function preservation1
Clustered friction triggers scratching that repeatedly interrupts skin recovery
Where this hypothesis actsDuring mechanical interception of scratch contacts
What is proposedPreserve sensory afferent activity needed for protective sensation
With whatPhysical or surgical intervention
HowIntercept scratch contacts without suppressing sensory afferents; evaluate thermal detection, mechanical detection, and protective response latency separately
Possible resultExpected preservation of protective sensation while inflammatory recovery settles
2026-09-21
Feedback restoration1
Cold-sensing nerve adaptation may delay response shutdown after sweating and blood flow stop
Where this hypothesis actsDuring sequential temperature transitions caused by mismatched cessation of sweating and blood flow
What is proposedRestore distinguishable sensory information about successive temperature changes
With whatChange of environment or regimen
HowApply a brief temperature signal to a remote, nonoverlapping receptor field during the second transition, keeping gland temperature and total external thermal input unchanged
Possible resultPossible restoration of timely thermoregulatory response termination and stabilization of SPV_8
2026-09-25