Live·Open questions in longevity research
All targets

Enzyme

V8 protease

A microbial protease implicated in signalling through PAR1

Hypotheses on this target 1

V8 proteaseInhibition. Hypotheses on this target 0Activation. Hypotheses on this target 11Lower level. Hypotheses on this target 0Higher level. Hypotheses on this target 0Replacement. Hypotheses on this target 0Protection from degradation. Hypotheses on this target 0Cofactor removal. Hypotheses on this target 0Synthesis suppression. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Inhibition
  • Activation1
  • Lower level
  • Higher level
  • Replacement
  • Protection from degradation
  • Cofactor removal
  • Synthesis suppression
  • Function preservation

Activation1

  • A microbial protease may limit skin inflammation through a nerve-to-immune signal

    Where this hypothesis actsAgeing skin after scratching has been prevented, with microbial load held constant

    What is proposedRestore V8 activity

    With whatNot stated in the record

    HowNot stated in the record

    Possible resultPossible shorter barrier recovery and inflammation duration when neuronal PAR1 remains functional

    2026-09-26