Receptor or channel
PAR1
A protease-activated receptor involved in signalling at sensory nerve endings
Hypotheses on this target 1
Lower level
Higher level
Blockade1
Agonism
Desensitisation
Function restoration
Function preservation
Blockade1
A microbial protease may limit skin inflammation through a nerve-to-immune signal
Where this hypothesis actsSensory neurons innervating skin after scratching has been prevented
What is proposedSelectively switch off PAR1 in neurons to test its role
With whatNot stated in the record
HowSelective receptor shutdown in neurons in an experimental model; the technique is not stated
Possible resultExpected disappearance of the beneficial effect of V8
2026-09-26