Live·Open questions in longevity research
All targets

Enzyme

NOTUM

A secreted enzyme that suppresses WNT-dependent recovery of neighboring cells

Hypotheses on this target 1

NOTUMInhibition. Hypotheses on this target 11Activation. Hypotheses on this target 0Lower level. Hypotheses on this target 0Higher level. Hypotheses on this target 0Replacement. Hypotheses on this target 0Protection from degradation. Hypotheses on this target 0Cofactor removal. Hypotheses on this target 0Synthesis suppression. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Inhibition1
  • Activation
  • Lower level
  • Higher level
  • Replacement
  • Protection from degradation
  • Cofactor removal
  • Synthesis suppression
  • Function preservation

Inhibition1

  • Altered cells may suppress normal repair through an enzyme above a local abundance threshold

    Where this hypothesis actsSecreted by altered cells during a spermidine pulse coinciding with feeding

    What is proposedSuppress NOTUM for a limited time

    With whatControlled genetic model

    HowTime-limited NOTUM suppression combined with an autophagy mimetic; genetic Notum inactivation tests the mechanism

    Possible resultPossible loss of the threshold-dependent competitive advantage while preserving normal-cell autophagy

    2026-10-06