Gene and its expression
IFT88
A gene with functions in ciliogenesis and beyond ciliogenesis
Hypotheses on this target 1
Gene editing1
Silencing
Expression induction
Gene replacement therapy
Repair
Gene editing1
Rebuilding skin anchorage can enable tumor initiation by restoring cellular signaling
Where this hypothesis actsSMO-mutant keratinocytes in aged human organotypic mosaics undergoing anchoring reconstruction
What is proposedDisrupt IFT88 selectively in mutant cells
With whatControlled genetic model
HowMutant-restricted inducible disruption, with genetic rescue and orthogonal perturbation to test ciliary dependence
Possible resultPossible prevention of reconstruction-associated invasion while retaining the mechanical benefit
2026-09-21