Live·Open questions in longevity research
All targets

Transporter

KCC2

A protein involved in neuronal chloride regulation and inhibitory signaling

Hypotheses on this target 1

KCC2Inhibition. Hypotheses on this target 0Lower level. Hypotheses on this target 0Higher level. Hypotheses on this target 0Blockade. Hypotheses on this target 0Agonism. Hypotheses on this target 0Function restoration. Hypotheses on this target 11

Function restoration1

  • Altered neuronal chloride regulation may prolong sleep and autonomic disruption after awakening

    Where this hypothesis actsHypothalamic stress-output neurons after repeated awakenings in an ovarian-withdrawal model

    What is proposedRestore KCC2 function to normalize the chloride reversal potential

    With whatNot stated in the record

    HowCell-targeted KCC2 manipulation; the specific manipulation is not stated in the record

    Possible resultExpected normalization of post-awakening cardiovascular recovery and sleep re-entry without restoring flashes

    2026-10-05