Signalling molecule
Phenol-soluble modulins alpha (PSMα)
Bacterial products that activate keratinocytes and can trigger an inflammatory response
Hypotheses on this target 1
Lower level
Synthesis suppression
Neutralisation1
Supplementation
Accelerated excretion
Neutralisation1
Parallel routes activating skin cells may sustain barrier damage after protease suppression
Where this hypothesis actsEpidermis after scratching has stopped and microbial proteases have been suppressed
What is proposedSuppress PSMα activity separately and together with TLR2 activity
With whatNot stated in the record
HowNot stated in the record
Possible resultExpected residual damage with PSMα blockade alone; combined blockade may reduce new damage to the young reference range
2026-09-25