Live·Open questions in longevity research

Rhythm or programme

Primary cilium assembly

The formation or reformation of primary cilia on cells

Hypotheses on this target 1

Primary cilium assemblyInhibition. Hypotheses on this target 0Activation. Hypotheses on this target 11Function preservation. Hypotheses on this target 0Feedback restoration. Hypotheses on this target 0Rhythm restoration. Hypotheses on this target 0Direct measurement. Hypotheses on this target 0
  • Inhibition
  • Activation1
  • Function preservation
  • Feedback restoration
  • Rhythm restoration
  • Direct measurement

Activation1

  • Synchronized cilium loss may prolong skin growth by removing a brake on cell-cycle re-entry

    Where this hypothesis actsRecovering dermal fibroblasts after initial migration and between treatment exposures

    What is proposedRestore primary cilia after initial migration

    With whatNot stated in the record

    HowIntervene in cilium assembly with two independent verification methods and restoration of the original phenotype; specific interventions are not stated

    Possible resultPossible restraint of cell-cycle re-entry and elimination of the advantage of distributed clock phases

    2026-09-25