Rhythm or programme
Mitophagy
The delivery of mitochondria to lysosomes and removal of whole mitochondria
Hypotheses on this target 3
Inhibition1
Activation2
Function preservation
Feedback restoration
Rhythm restoration
Direct measurement
Inhibition1
Lysosomal acidity may mimic faster mitochondrial removal
Where this hypothesis actsDuring mTOR suppression, when testing whether mitophagy mediates lifespan extension
What is proposedBlock mitophagy to test whether the lifespan benefit persists
With whatControlled genetic model
HowSwitch off a selected, unnamed gene and independently track labelled mitochondrial delivery and destruction to verify blockade beyond reporter acidity effects
Possible resultExpected persistence of lifespan extension despite verified mitophagy blockade
2026-09-30
Activation2
Organelle renewal and senescent cell clearance may provide independent lasting benefits
Where this hypothesis actsCardiomyocytes and muscle fibres with impaired breakdown and replacement of damaged organelles
What is proposedRestore completed mitophagy flux
With whatNot stated in the record
HowNot stated in the record
Possible resultPossible lasting benefits across multiple systems and longer lifespan, independently of senescent cell clearance
2026-09-30
Restoring mitochondrial renewal may account for all lasting benefits of the tested interventions
Where this hypothesis actsSurviving parenchymal cells, including cardiomyocytes and muscle fibres, during ageing
What is proposedRestore mitophagy in surviving cells
With whatControlled genetic model
HowInducible genetic interventions to switch mitophagy off and restore it, with mitophagy reporters to track the response
Possible resultPossible sustained functional benefits across multiple systems and increased lifespan
2026-09-30