Nyquist stability boundary

Telling states apart2

• Measurement delays create the appearance of unstable glucose control after muscle restoration

  Where this hypothesis actsGlucose control during externally forced meal-activity transients with stronger muscle insulin responsiveness

  What is proposedDistinguish an apparent instability boundary from physiological glucose instability

  With whatInstrument or assay

  HowCalibrate observation delays independently, synchronize reference glucose and glucose-flux measurements, and test held-out perturbations

  Possible resultPossible elimination of the apparent boundary while reference glucose responses remain stable

  2026-09-20

• Apparent benefits of timing alignment after partial tissue replacement are measurement artifacts

  Where this hypothesis actsPredicting timing-mediated rescue after reduced-fraction replacement

  What is proposedTest independently fitted stability predictions on held-out episodes

  With whatInstrument or assay

  HowFit stability models independently and evaluate their predictions on held-out episodes

  Possible resultExpected failure of independently fitted stability models to predict held-out outcomes

  2026-09-18