Signalling pathway
Coagulation cascade
A sequence of catalytic reactions in which active coagulation enzymes generate further active enzymes
Hypotheses on this target 1
Inhibition1
Activation
Desensitisation
Function preservation
Feedback restoration
Rhythm restoration
Inhibition1
Estradiol may amplify clotting reactions past a self-sustaining threshold
Where this hypothesis actsBlood at matched systemic estradiol exposure, particularly during resumption with an inflammatory trigger
What is proposedSuppress catalytic propagation below its experimentally identified threshold
With whatNot stated in the record
HowSelectively inhibit a predicted high-contribution catalytic reaction while preserving coagulation initiated downstream by a matched thrombin input
Possible resultPossible elimination of estradiol-associated excess thrombin generation while preserving downstream coagulation
2026-10-03