Rhythm or programme
Endocrine fluctuations
Variations in endocrine exposure over time in perimenopausal participants
Hypotheses on this target 2
Inhibition1
Activation
Function preservation
Feedback restoration
Rhythm restoration1
Direct measurement
Inhibition1
Estrogen receptor competition may divert gene-activation support away from cellular repair
Where this hypothesis actsEndocrine peaks activating estrogen receptors in the perimenopausal setting
What is proposedReduce endocrine peaks that drive competition for the shared coactivator
With whatNot stated in the record
HowNot stated in the record
Possible resultPossible preservation of function through reduced competition with cellular repair programs
2026-10-03
Rhythm restoration1
Hormone fluctuations may preserve tissue responsiveness by allowing estrogen receptors to renew
What is proposedPreserve appropriately spaced fluctuations and increase selected fluctuations
With whatChange of environment or regimen
HowUse interrupted estradiol delivery with low-exposure intervals exceeding measured receptor-recovery time, matching integrated exposure and holding other steroids constant
2026-10-03