Live·Open questions in longevity research
All targets

Rhythm or programme

Ferroptosis

Iron-dependent cell death caused by lipid peroxidation

Hypotheses on this target 2

FerroptosisInhibition. Hypotheses on this target 11Activation. Hypotheses on this target 0Function preservation. Hypotheses on this target 0Feedback restoration. Hypotheses on this target 0Rhythm restoration. Hypotheses on this target 0Direct measurement. Hypotheses on this target 0
  • Inhibition1
  • Activation
  • Function preservation
  • Feedback restoration
  • Rhythm restoration
  • Direct measurement

Inhibition1

  • Suppressing a prostaglandin receptor may curb ferroptosis through itaconate

    Where this hypothesis actsMuscle, heart and lung cells exposed to neutrophil-associated inflammatory damage

    What is proposedSuppress ferroptosis directly in target cells

    With whatNot stated in the record

    HowDirect suppression in target cells during continued blockade of neutrophil engulfment; the intervention is not specified

    Possible resultPossible restoration of functional benefits lost after macrophage-specific ACOD1 inactivation

    2026-09-30