Live·Open questions in longevity research
All targets

Extracellular nucleic acid

RNA–DNA hybrids

Structures formed by RNA and DNA that can obstruct transcription and contribute to genomic damage

Hypotheses on this target 1

RNA–DNA hybridsSilencing. Hypotheses on this target 0Clearance restoration. Hypotheses on this target 11Neutralisation. Hypotheses on this target 0Accelerated excretion. Hypotheses on this target 0

Clearance restoration1

  • Reducing ribosomal gene transcription may protect tissues by limiting genome damage

    Where this hypothesis actsPathological hybrids in ribosomal genes in ageing cells

    What is proposedReduce the formation or persistence of pathological RNA–DNA hybrids

    With whatProtein or peptide as the agent

    HowSuppress mTOR or remove hybrids using ribonuclease H1 with verified nuclear localization and controls for mitochondrial effects

    Possible resultPossible reduction in new ribosomal gene breaks and reproduction of the protective effect of mTOR suppression

    2026-09-30