Indicator or biomarker
Cognitive performance measurements
Scores and observations used to assess cognitive performance
Hypotheses on this target 2
Telling states apart2
Direct measurement
Indicator replacement
Telling states apart2
The apparent cognitive deficit during walking and posture changes comes from measurement errors
Where this hypothesis actsDuring combined walking and posture transitions
What is proposedDistinguish cognitive impairment from stimulus delivery and response execution errors
With whatInstrument or assay
HowVerify stimulus delivery, balance gait-phase sampling, use response-free encoding and delayed stationary recognition, and vary response modality at the same walking dose
Possible resultExpected disappearance of the timing effect when observation errors are controlled
2026-09-18
Apparent benefits of timing alignment after partial tissue replacement are measurement artifacts
Where this hypothesis actsTesting apparent timing-mediated rescue after reduced-fraction replacement
What is proposedDistinguish cognitive improvement from testing-phase, practice and selection effects
With whatInstrument or assay
HowUse randomized, counterbalanced comparisons, matched challenges, alternate cognitive tasks, full-cycle sampling and retention of all assigned episodes
Possible resultExpected absence of clinically meaningful cognitive improvement, with bounds excluding the prespecified rescue effect
2026-09-18