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All targets

Signalling molecule

TGF-β1

A signalling molecule secreted by M2 macrophages that can drive fibroblast activation

Hypotheses on this target 1

TGF-β1Lower level. Hypotheses on this target 0Synthesis suppression. Hypotheses on this target 0Neutralisation. Hypotheses on this target 11Supplementation. Hypotheses on this target 0Accelerated excretion. Hypotheses on this target 0
  • Lower level
  • Synthesis suppression
  • Neutralisation1
  • Supplementation
  • Accelerated excretion

Neutralisation1

  • The fibrosis signal is stopped by the hyaluronan mesh, not by the macrophage

    Where this hypothesis actsBetween M2 macrophages and niche fibroblasts in human explant co-cultures

    What is proposedPrevent TGF-β1 from reaching niche fibroblasts in a functional concentration

    With whatPhysical or surgical intervention

    HowUse an ultra-HMW-HA coat to sequester TGF-β1 through HA-bound LTBP and prevent integrin αvβ6-mediated mechanical activation

    Possible resultPossible suppression of fibroblast αSMA expression even with high TGF-β1 secretion

    2026-09-14