Epithelial cells

Elimination2

• Loss of mucosal barriers may let microbial toxins create mutations that drive invasion

  Where this hypothesis actsResident lineages in older-donor intestinal epithelial mosaics undergoing repeated repair

  What is proposedRemove a limited area of resident cells to test their protective barrier contribution

  With whatPhysical or surgical intervention

  HowCompare controlled small-area removal with retention and viability-preserving suppression, matching initial injury and testing functional replacement

  Possible resultPossible increased toxin exposure and new invasive descendants if removal disrupts functional protection

  2026-10-10

• Dead resident cells may feed invasive lineages during epithelial repair

  Where this hypothesis actsResident populations in aging human epithelial mosaics containing a pre-existing invasive lineage

  What is proposedCompare resident killing with retained debris against physical extraction and retention

  With whatPhysical or surgical intervention

  HowCompare retention, viability-preserving suppression, killing with retained debris and extraction; prelabel resident biomass and trace its release and use

  Possible resultPossible extra invader survival or production when resident death supplies accessible, metabolically useful material

  2026-10-10