Receptor or channel
CD40
A recipient B-cell target whose blockade tests whether helper signals sustain recall-cell participation
Hypotheses on this target 1
Lower level
Higher level
Blockade1
Agonism
Desensitisation
Function restoration
Function preservation
Blockade1
Memory helper cells can sustain recall responses without the responding cells presenting antigen
Where this hypothesis actsHLA-II-negative recall B cells in aged-donor lymphoid cultures with activated memory Tfh cells
What is proposedBlock CD40 specifically on recipient recall B cells
With whatNot stated in the record
HowRecipient-specific CD40 blockade during repeated exposure with high familiar-epitope antibody occupancy
Possible resultExpected elimination of helper-mediated rescue of HLA-II-negative recall B cells
2026-09-21