Lipid
Lipid A
A bacterial lipid whose fully acylated form can remain biologically active after microbial clearance
Hypotheses on this target 1
Lower level
Neutralisation1
Supplementation
Composition restoration
Neutralisation1
Active bacterial lipids left after clearance renew inflammation after injury
Where this hypothesis actsPersistent fully acylated material after Gram-negative clearance, during a subsequent mild injury
What is proposedReduce lipid A agonist activity through deacylation
With whatProtein or peptide as the agent
HowRestore acyloxyacyl hydrolase activity through local enzyme supplementation or expression
Possible resultPossible prevention of renewed inflammation and differentiation loss after a subsequent mild injury
2026-09-21