Mechanics and load
Cutaneous vasodilation
Dilation of blood vessels in the skin, contributing to peripheral dry heat loss
Hypotheses on this target 1
Inhibition1
Activation
Function preservation
Remodelling
Load normalisation
Direct measurement
Inhibition1
Persistent local histamine action may prolong skin heat loss and cause post-flash cold rebound
What is proposedTerminate the prolonged local vascular response after a flash
With whatSmall molecule
HowLocally administer H1/H2 blockade through paired-site microdialysis after the event, keeping neural activity and early flash recruitment comparable
2026-10-03