Signalling molecule
Interleukin-6
A secreted signalling molecule
Hypotheses on this target 2
Lower level
Synthesis suppression1
Neutralisation1
Supplementation
Accelerated excretion
Synthesis suppression1
Interleukin-6 from blood-forming stem cells may sustain organ damage while preserving defense
Where this hypothesis actsSecreted by hematopoietic stem cells with inflammatory memory during ageing, between infection episodes
What is proposedSuppress interleukin-6 synthesis and secretion in hematopoietic stem cells
With whatControlled genetic model
HowInducible restriction of expression specifically in stem cells after memory formation, while preserving descendants' protective memory
Possible resultPossible reduction in sustained systemic exposure and lung and kidney damage before mature myeloid cell turnover
2026-09-30
Neutralisation1
Blocking junction repair may align defects across skin layers and increase penetration
Where this hypothesis actsSkin exposed to wet friction, with itch reduction matched between interventions
What is proposedSelectively suppress IL-31 while preserving junction repair
With whatNot stated in the record
HowIL-31 blockade that leaves TRPV4-dependent junction repair intact; the blocking agent is not stated
Possible resultPossible preservation of junction repair and better prevention of repeated skin damage
2026-09-25