Enzyme
mTORC1
Complex 1 of the mechanistic target of rapamycin, a protein complex targeted for suppression by rapamycin
Hypotheses on this target 2
Inhibition1
Activation
Lower level
Higher level
Replacement
Protection from degradation
Cofactor removal
Synthesis suppression
Function preservation
Inhibition1
Error-prone muscle protein rebuilding may limit lifespan gains from intermittent rapamycin
Where this hypothesis actsIntermittent fasting-mimetic treatment
What is proposedSuppress mTORC1 in short pulses
With whatNot stated in the record
HowUse a proposed fasting mimetic that combines brief mTORC1 suppression with moderate restriction of translation initiation between pulses
Possible resultExpected maintenance of pathway suppression and comparable antitumor activity while testing added lifespan benefit
2026-10-06