Live·Open questions in longevity research
All targets

Enzyme

SIRT6

An enzyme that mediates deacetylation of the histone mark H3K9ac at the TGFB1 promoter

Hypotheses on this target 1

SIRT6Inhibition. Hypotheses on this target 0Activation. Hypotheses on this target 11Lower level. Hypotheses on this target 0Higher level. Hypotheses on this target 0Replacement. Hypotheses on this target 0Protection from degradation. Hypotheses on this target 0Cofactor removal. Hypotheses on this target 0Synthesis suppression. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Inhibition
  • Activation1
  • Lower level
  • Higher level
  • Replacement
  • Protection from degradation
  • Cofactor removal
  • Synthesis suppression
  • Function preservation

Activation1

  • NAD+ decides whether a healing macrophage also turns fibrotic

    Where this hypothesis actsAged human macrophages with insufficient SIRT6 activity during SPM-driven M2 polarization

    What is proposedRestore SIRT6-mediated histone deacetylation

    With whatSmall molecule

    HowRestore activity through NAD+ repletion with NMN or NR; test dependence on SIRT6 using the inhibitor OSS_128167

    Possible resultExpected TGFB1 silencing while SPM-driven IL-10/Arg1 upregulation proceeds

    2026-09-14