Live·Open questions in longevity research
All targets

Rhythm or programme

Lysosomal membrane permeabilization

Loss of lysosomal membrane integrity that allows lysosomal contents to escape into the cell

Hypotheses on this target 1

Lysosomal membrane permeabilizationInhibition. Hypotheses on this target 0Activation. Hypotheses on this target 11Function preservation. Hypotheses on this target 0Feedback restoration. Hypotheses on this target 0Rhythm restoration. Hypotheses on this target 0Direct measurement. Hypotheses on this target 0
  • Inhibition
  • Activation1
  • Function preservation
  • Feedback restoration
  • Rhythm restoration
  • Direct measurement

Activation1

  • Estrogen re-exposure may kill breast cell lineages by rupturing deprivation-altered lysosomes

    Where this hypothesis actsSusceptible breast lineages during estrogen re-exposure after prolonged deprivation

    What is proposedTrigger lysosomal membrane permeabilization

    With whatSmall molecule

    HowRe-expose estrogen-deprived breast lineages to estrogen, increasing endocytic cargo handling

    Possible resultPossible elimination of susceptible breast lineages through an involution-related death program

    2026-10-03