Gene and its expression
UV photolesions
DNA lesions caused by ultraviolet exposure
Hypotheses on this target 1
Gene editing
Silencing
Expression induction
Gene replacement therapy
Repair1
Repair1
Renewal signals turn lingering ultraviolet damage into lasting mutations in aged skin
Where this hypothesis actsPhotoaged skin undergoing repeated EGFR stimulation with inadequate stromal IGF-1 support
What is proposedRepair UV photolesions before stimulating renewal
With whatNot stated in the record
HowValidated lesion-specific photorepair before stimulation
Possible resultPossible prevention of excess new mutations and persistent clonal advantage while retaining assisted closure
2026-09-21