Signalling pathway
NF-κB activation
Activation of the nuclear factor NF-κB within an intracellular inflammatory cascade
Hypotheses on this target 1
Inhibition1
Activation
Desensitisation
Function preservation
Feedback restoration
Rhythm restoration
Inhibition1
Inflammatory fluctuations may repeatedly activate nuclear factor kappa B and delay skin repair
Where this hypothesis actsLocal immune cells after a sleep shift, during repeated treatments timed to epidermal rhythms
What is proposedReduce the probability of repeated NF-κB activation between treatments
With whatChange of environment or regimen
HowChoose treatment timing using individually estimated probabilities of inflammatory reactivation rather than average intertissue phase delays alone
Possible resultPossible reduction in persistent inflammation, residual dermal proliferation and incomplete repair
2026-09-25