Live·Open questions in longevity research
All targets

Receptor or channel

TLR2

A receptor through which bacterial lipoproteins activate keratinocytes

Hypotheses on this target 1

TLR2Lower level. Hypotheses on this target 0Higher level. Hypotheses on this target 0Blockade. Hypotheses on this target 11Agonism. Hypotheses on this target 0Desensitisation. Hypotheses on this target 0Function restoration. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Lower level
  • Higher level
  • Blockade1
  • Agonism
  • Desensitisation
  • Function restoration
  • Function preservation

Blockade1

  • Parallel routes activating skin cells may sustain barrier damage after protease suppression

    Where this hypothesis actsEpidermis after scratching has stopped and microbial proteases have been suppressed

    What is proposedSuppress TLR2 activity separately and together with PSMα activity

    With whatNot stated in the record

    HowNot stated in the record

    Possible resultExpected residual damage with TLR2 blockade alone; combined blockade may reduce new damage to the young reference range

    2026-09-25