Live·Open questions in longevity research
All targets

Enzyme

ACOD1

An enzyme involved in itaconate synthesis

Hypotheses on this target 1

ACOD1Inhibition. Hypotheses on this target 11Activation. Hypotheses on this target 0Lower level. Hypotheses on this target 0Higher level. Hypotheses on this target 0Replacement. Hypotheses on this target 0Protection from degradation. Hypotheses on this target 0Cofactor removal. Hypotheses on this target 0Synthesis suppression. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Inhibition1
  • Activation
  • Lower level
  • Higher level
  • Replacement
  • Protection from degradation
  • Cofactor removal
  • Synthesis suppression
  • Function preservation

Inhibition1

  • Suppressing a prostaglandin receptor may curb ferroptosis through itaconate

    Where this hypothesis actsMacrophages during EP2 suppression and blockade of neutrophil engulfment

    What is proposedInactivate ACOD1 specifically in macrophages

    With whatControlled genetic model

    HowConditional, macrophage-specific inactivation; the implementation is not stated

    Possible resultExpected loss of the functional benefit if macrophage-derived itaconate is required

    2026-09-30