Organ structure
Skin tissue
Tissue comprising the epidermis, dermis and skin appendages, with vascular and nerve connections
Hypotheses on this target 4
Function restoration2
Remodelling
Tissue graft2
Load normalisation
Function restoration2
Local maintenance may interrupt accumulating random skin-function deviations before youthful limits
Where this hypothesis actsEpidermis, dermis and appendages during initial restoration and ten years of local maintenance
What is proposedRestore skin structures and maintain their functions within young reference ranges
With whatNot stated in the record
HowR_P proposes restoring existing cells; R_T proposes tissue replacement. Each alternative includes limited local maintenance; biological implementations remain undeveloped
Possible resultPossible maintenance of all skin functions for ten years within predefined maintenance burden and risk limits
2026-09-25
Aging skin can sustain youthful function without rejuvenating its resident cells
Where this hypothesis actsAcross every applicable anatomical-site stratum, with persistently old resident cells
What is proposedRestore the biological state coordinates C01–C16
With whatNot stated in the record
HowRestore each coordinate across at least 95% of its eligible area, volume or resident structures in every applicable anatomical-site stratum; coordinate identities are not stated
Possible resultPossible twenty-year maintenance of youthful skin performance during repeated combined challenges
2026-09-21
Tissue graft2
Targeted small tissue grafts may restore skin function by reconnecting surviving tissue
Where this hypothesis actsSites of broken connections between retained functional regions of the epidermis, dermis and skin appendages
What is proposedReplace the minimum set of tissue sites needed to reconnect functional regions
With whatPhysical or surgical intervention
HowPlace complete autologous micrografts using a tissue connectivity map, replacing ≤10% of regional skin volume; assess annually and replace disconnected sites at ≤1% per year
Possible resultPossible restoration of coordinated skin function across the region, including the retained ≥90% of tissue
2026-09-26
Distributed skin micrografts may restore surrounding skin through complete functional units
Where this hypothesis actsAgeing skin across the treatment area
What is proposedPartially replace skin with complete, spatially distributed microtransplants
With whatPhysical or surgical intervention
HowIntegrate complete skin microtransplants on a triangular grid, replacing about 13.4% of the area; replace lost units at most annually without increasing their initial number
Possible resultPossible restoration of skin functions throughout the area, extending to three graft radii around each unit
2026-09-25