Signalling pathway
Gap junction communication
Communication between cells through functional junctional channels that relay intercellular signals
Hypotheses on this target 2
Inhibition
Activation2
Desensitisation
Function preservation
Feedback restoration
Rhythm restoration
Activation2
Skin cells restrain abnormal clones by relaying signals that end repair
Where this hypothesis actsBasal keratinocyte networks during repair after compliance restoration, including mutant neighborhoods
What is proposedRestore connected calcium-signal propagation before renewal accelerates
With whatNot stated in the record
HowStaged reconstruction to restore a spanning communication network before renewal accelerates, preserving cell viability, adhesion, and matrix mechanics
Possible resultPossible restoration of repair termination and suppression of persistent mutant cycling and invasion
2026-09-21
Clearing senescent bone-forming cells may weaken repair by breaking cell communication
Where this hypothesis actsSurviving nonsenescent cells during bone repair after senescent-cell clearance
What is proposedRestore junctional coupling after senescent-cell clearance
With whatNot stated in the record
HowNot stated in the record
Possible resultPossible rescue of repair through restored formation-resorption coupling without restoring senescent burden
2026-10-03