Eternal Search - the palantir of the longevity world
Without a picture of the whole field, work becomes motion that feels useful and changes nothing. So we take all of it: every company, every result, every argument. And the map has to go past who does what, to the hierarchy of problems, to what causes what, and to how new ideas get made at all. We study the thinking itself.
Extending life is a task of superhuman complexity, and AI agents are the only way to scale it. Head count in the field grows slowly; the number of agents can grow ten, a hundred, a thousand, ten thousand times in a year. That is how we hold the whole field in view, reason about it deeply, and work on ageing at every level, from the cell to how society interacts.
Everything we learn has to end in a tool someone can use the same day: a verified grant, a rated project, a readable protocol, a completed experiment. The output is always an instrument, ready for work.
Eight questions that measure our progress
Longer lives. Replaceable tissues. Simulated brains. Explore what we can do now, how we got here, and what we still cannot measure.
Each chart shows years and measured values. Select a direction for the evidence.
Each chart has its own units and scale. Connecting lines link published observations; intervening years have not been measured here.
The question
How much life has an intervention added, in the longest-lived mammal, when started as late as possible?
What the evidence says
Mice · treatment from week 124 · 2024
The three records do not coincide. In the studies below, OSK began at 124 weeks in male mice and added about 9.6 weeks of median remaining life. Rhesus macaques extend the species horizon to decades, but their late-onset restriction groups showed no significant survival advantage. An overall record combining all three conditions is not established here.
Large remaining-life percentages can correspond to weeks. Median lifespan, late-survival endpoints and individual records must be compared separately. These animal results do not establish a human lifespan benefit.
Track species longevity, sex, starting age, absolute days gained, total-life and remaining-life effects, sample size and independent replication together.
Male / female mice: increase in age at 90% mortality, observed at three sites. This endpoint differs from median remaining life.
Age at restriction onset in the Wisconsin study. Controls had 1.865 times the mortality hazard of restricted macaques. The separate NIA old-onset groups showed no significant survival difference.
Male mice, start at 124 weeks: 8.86 → 18.5 weeks of median remaining life, about 9.6 weeks gained. Total median lifespan was approximately 133 → 142.5 weeks. OSK denotes OCT4, SOX2 and KLF4. One study, not a confirmed cross-laboratory record.
Antibody treatment from 75 weeks of age increased total median lifespan in male / female mice. The intervention began earlier than the OSK study.
Oxytocin plus an ALK5 inhibitor: remaining lifespan +73%, total median +14% in males (14 treated, 12 controls). Females showed no lifespan benefit. The correction adds a conflict-of-interest disclosure.
Female mice: total median lifespan 742 → 834 days, a calculated 12.4% increase. Published 2 September 2026. A later publication does not automatically set a higher record.
This is a dated, source-linked selection, not an exhaustive record registry. Publication years are shown unless a milestone explicitly names an earlier event. Different species, endpoints, surveys and accounting methods stay separate. Gaps mean that a comparable measure was not established in this review.
Sequencing costs are nominal US dollars for a human-sized genome. The cost plot is logarithmic. Sequencing is one component of an experiment; its price does not measure the total cost of testing an ageing hypothesis.
We draw on 2,000 sources every day. Discoveries, trials, companies, funding, and the public decisions that change the field.
02EssaysState positions, develop ideas, and argue about scientific and strategic choices in public.
03PostersTurn scientific papers into visual explanations that can be understood, shared, and printed.
04ProtocolsOrganise evidence for interventions while keeping uncertainty and limits visible.
05PresentationsBuild maps for the largest questions: what ageing is, how difficult it may be, and which strategies follow from each answer.
06FilmLONGEVITY is a 90-minute documentary shot inside the labs where ageing is being taken apart: cryopreservation, genome editing, and the animals that barely age at all. Co-produced by Open Longevity, in production for 2027.
Eternal Search is a project of Open Longevity, a California nonprofit public benefit corporation recognised by the IRS as tax-exempt under section 501(c)(3). EIN 85-2518777. Sherman Oaks, California.
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