Metabolism and energy
Oxidative capacity
The capacity to support oxidative metabolism
Hypotheses on this target 2
Inhibition
Activation1
Function preservation1
Supplementation
Feedback restoration
Direct measurement
Activation1
Restored muscle overwhelms the liver's energy capacity to recycle lactate into glucose
Where this hypothesis actsLiver receiving matched substrate and hormone waveforms in perfusion experiments
What is proposedIncrease oxidative capacity selectively
With whatNot stated in the record
HowNot stated in the record
Possible resultPossible restoration of glucose production under matched substrate and hormone delivery
2026-09-18
Function preservation1
Mitochondrial genome deletions hide a loss of muscle energy reserve
Where this hypothesis actsRetained muscle fiber segments with high mitochondrial deletion heteroplasmy and reduced oxidative reserve
What is proposedPreserve oxidative capacity
With whatNot stated in the record
HowNot stated in the record
Possible resultPossible stabilization of SPV_6
2026-09-18