Organ structure
Stromal contacts
Physical contact sites provided by stromal cells that support resident cells
Hypotheses on this target 1
Function restoration
Remodelling1
Tissue graft
Load normalisation
Remodelling1
New antibody-producing cell clusters can kill older cells by changing nearby survival signals
Where this hypothesis actsMarrow survival niches receiving incoming plasmablast clusters
What is proposedArrange stromal contacts into spatially separated islands
With whatPhysical or surgical intervention
HowUse micropatterned stromal cultures and marrow organoids to vary contact geometry while keeping cell numbers and total contact area matched
Possible resultPossible preservation of old plasma cells through additional independent survival domains
2026-09-21