Live·Open questions in longevity research
All targets

Metabolite or ion

NAD+

A molecule whose availability supports SIRT6 activity and contributes to the mitochondrial NAD+/NADH ratio

Hypotheses on this target 1

NAD+Supplementation. Hypotheses on this target 11Accelerated excretion. Hypotheses on this target 0Composition restoration. Hypotheses on this target 0

Supplementation1

  • NAD+ decides whether a healing macrophage also turns fibrotic

    Where this hypothesis actsAged human macrophages with depleted NAD+ undergoing SPM-driven M2 polarization

    What is proposedIncrease NAD+ availability

    With whatSmall molecule

    HowReplete NAD+ using NMN or NR; the proposed test uses NMN at 1 mM for 48 hours before SPM-driven M2 polarization

    Possible resultExpected restoration of TGFB1 silencing and reduced TGF-β1 secretion during M2 polarization

    2026-09-14