Live·Open questions in longevity research
All targets

Receptor or channel

FPR2/ALX receptor

A receptor whose signaling output can depend on its phosphorylation and desensitization state

Hypotheses on this target 1

FPR2/ALX receptorLower level. Hypotheses on this target 0Higher level. Hypotheses on this target 0Blockade. Hypotheses on this target 0Agonism. Hypotheses on this target 11Desensitisation. Hypotheses on this target 0Function restoration. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Lower level
  • Higher level
  • Blockade
  • Agonism1
  • Desensitisation
  • Function restoration
  • Function preservation

Agonism1

  • Resolvins may drive fibrosis in aged cells rather than resolve it

    Where this hypothesis actsAged human macrophages with desensitized receptors and documented low FPR2 surface density

    What is proposedStimulate the receptor with resolvin D1

    With whatSmall molecule

    HowTreat aged human macrophages with resolvin D1 and measure TGF-β1 secretion by ELISA

    Possible resultPossible increase in TGF-β1 secretion through β-arrestin-biased signaling

    2026-09-14