Live·Open questions in longevity research
All targets

Receptor or channel

CD47

A protein that provides a contact signal restraining macrophage activity

Hypotheses on this target 1

CD47Lower level. Hypotheses on this target 0Higher level. Hypotheses on this target 0Blockade. Hypotheses on this target 11Agonism. Hypotheses on this target 0Desensitisation. Hypotheses on this target 0Function restoration. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Lower level
  • Higher level
  • Blockade1
  • Agonism
  • Desensitisation
  • Function restoration
  • Function preservation

Blockade1

  • Senescent fibroblasts may strengthen healed skin by briefly slowing dead-cell clearance

    Where this hypothesis actsOn confirmed senescent fibroblasts during early skin healing

    What is proposedSelectively block CD47 early to test its proposed protective role

    With whatNot stated in the record

    HowSelectively block CD47 on confirmed senescent fibroblasts while keeping the fibroblasts intact

    Possible resultExpected faster dead-cell engulfment, lower later skin strength and greater residual deformation

    2026-09-26