Rhythm or programme
DNA replication licensing
Preparation of replication initiation sites before DNA synthesis, involving loading of the MCM2-7 helicase complex
Hypotheses on this target 1
Inhibition
Activation
Function preservation
Feedback restoration
Rhythm restoration1
Direct measurement
Rhythm restoration1
Premature DNA copying may damage resting cells as they resume growth and favour altered clones
Where this hypothesis actsNormal cells entering their first DNA replication after leaving quiescence
What is proposedAllow replication preparation to finish before the first S phase
With whatChange of environment or regimen
HowSeparate the autophagic pulse from strong nutrient signaling, or briefly extend G1 through reversible action on cyclin-dependent kinases while preserving autophagy
Possible resultPossible reduction in DNA damage in normal cells and in the subsequent advantage of the altered clone
2026-10-06