Live·Open questions in longevity research
All targets

Receptor or channel

PD-1

An immune checkpoint receptor that mediates restraint of cytotoxic-cell encounters

Hypotheses on this target 1

PD-1Lower level. Hypotheses on this target 0Higher level. Hypotheses on this target 0Blockade. Hypotheses on this target 0Agonism. Hypotheses on this target 11Desensitisation. Hypotheses on this target 0Function restoration. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Lower level
  • Higher level
  • Blockade
  • Agonism1
  • Desensitisation
  • Function restoration
  • Function preservation

Agonism1

  • Stronger immune restraint restores protective killing by ending unproductive cell contacts

    Where this hypothesis actsOlder-adult cytotoxic cells after verified pathogen control, before tissue repair is complete

    What is proposedIncrease PD-1-mediated restraint within a bounded range

    With whatAntibody or binding reagent

    HowReversible PD-1 agonism using Fc-silent reagents with demonstrated agonism and measured receptor engagement

    Possible resultPossible shorter bystander contacts, improved antiviral and abnormal-cell killing, and less uninfected-cell injury

    2026-09-21