Live·Open questions in longevity research
All targets

Enzyme

12-lipoxygenase

An enzyme that participates in converting lipid precursors into synthesis products

Hypotheses on this target 1

12-lipoxygenaseInhibition. Hypotheses on this target 11Activation. Hypotheses on this target 0Lower level. Hypotheses on this target 0Higher level. Hypotheses on this target 0Replacement. Hypotheses on this target 0Protection from degradation. Hypotheses on this target 0Cofactor removal. Hypotheses on this target 0Synthesis suppression. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Inhibition1
  • Activation
  • Lower level
  • Higher level
  • Replacement
  • Protection from degradation
  • Cofactor removal
  • Synthesis suppression
  • Function preservation

Inhibition1

  • Shared lipid synthesis in neutrophils and platelets may limit tissue damage

    Where this hypothesis actsPlatelets processing a neutrophil-derived precursor into lipoxins during EP2 suppression

    What is proposedDisable 12-lipoxygenase selectively in platelets

    With whatNot stated in the record

    HowPlatelet-specific inactivation while preserving neutrophil numbers, vesicular CD55 activity and itaconate flux

    Possible resultExpected loss of the benefit of EP2 suppression if platelet-dependent lipid synthesis is causal

    2026-09-30