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All targets

Antibody

M3 receptor autoantibodies

Autoantibodies that bind the muscarinic M3 receptor and block its function

Hypotheses on this target 1

M3 receptor autoantibodiesLower level. Hypotheses on this target 11Protection from degradation. Hypotheses on this target 0Synthesis suppression. Hypotheses on this target 0Neutralisation. Hypotheses on this target 0Accelerated excretion. Hypotheses on this target 0
  • Lower level1
  • Protection from degradation
  • Synthesis suppression
  • Neutralisation
  • Accelerated excretion

Lower level1

  • Autoantibodies may reduce sweating by blocking muscarinic receptors

    Where this hypothesis actsAssociated with sweat glands showing persistent secretion loss after normalization of skin mechanics

    What is proposedPrevent autoantibodies from blocking the M3 receptor

    With whatRemoval from a body fluid

    HowRemove the M3-binding immunoglobulin fraction while keeping tissue stiffness, duct patency and cholinergic stimulation unchanged

    Possible resultPossible restoration of the sweat component of SPV_8

    2026-09-25