Live·Open questions in longevity research
All targets

Enzyme

Ribosomes

Cellular machinery that translates transcripts into proteins

Hypotheses on this target 1

RibosomesInhibition. Hypotheses on this target 0Activation. Hypotheses on this target 11Lower level. Hypotheses on this target 0Higher level. Hypotheses on this target 0Replacement. Hypotheses on this target 0Protection from degradation. Hypotheses on this target 0Cofactor removal. Hypotheses on this target 0Synthesis suppression. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Inhibition
  • Activation1
  • Lower level
  • Higher level
  • Replacement
  • Protection from degradation
  • Cofactor removal
  • Synthesis suppression
  • Function preservation

Activation1

  • Estrogen re-exposure may kill deprived breast cell lineages through ribosome collisions

    Where this hypothesis actsDangerous breast cells after prolonged estrogen deprivation

    What is proposedIncrease translation initiation to provoke collisions involving stalled ribosomes

    With whatSmall molecule

    HowRe-expose estrogen-deprived cells to estrogen to increase translation initiation onto transcripts bearing stalled ribosomes

    Possible resultPossible selective killing of deprived lineages through collision-triggered ribotoxic stress

    2026-10-03