Mechanics and load
Stromal cell–matrix mechanical coupling
Mechanical feedback in which matrix resistance increases stromal cell traction, which further prestresses the matrix
Hypotheses on this target 1
Inhibition1
Activation
Function preservation
Remodelling
Load normalisation
Direct measurement
Inhibition1
A self-reinforcing pull between cells and tissue matrix sustains injury after clearance
Where this hypothesis actsAfter injury and restored efferocytosis, with persistent matrix prestress and stromal traction
What is proposedReduce traction-to-matrix coupling sufficiently to stabilize mechanical feedback
With whatPhysical or surgical intervention
HowUse tunable matrix anchoring and relaxation and controlled perturbations of stromal traction, leaving immune-cell history and matrix chemical composition unchanged
Possible resultPossible decay of matrix prestress and stromal traction, with declining injury
2026-09-21