Way of recording
Clone size measurement
A measurement of clone size using projected area or absolute lineage-labeled cell counts
Hypotheses on this target 1
Telling states apart1
Direct measurement
Indicator replacement
Telling states apart1
Tissue deformation makes restored skin flexibility appear to promote abnormal cell spread
Where this hypothesis actsIn tissue deformed by loading after compliance restoration
What is proposedDistinguish actual clone growth from deformation-induced increases in projected area
With whatInstrument or assay
HowUse tissue-following three-dimensional registration, absolute lineage-labeled cell counts, paired loaded/unloaded measurements, and fixed-tissue deformation controls
Possible resultExpected disappearance of the apparent increase in clone size after accounting for tissue deformation
2026-09-21